Stefano De Lillo è nato a Roma il 9 aprile 1962. Si è laureato con lode in Medicina e Chirurgia presso l’Università Cattolica del Sacro Cuore di Roma, dove ha poi conseguito la specializzazione in Cardiologia e quindi in Medicina dello Sport. È medico di base convenzionato con la Regione Lazio e medico convenzionato con il Fondo di Assistenza Sanitaria vaticana. È iscritto all'albo della Federazione Medico Sportiva Italiana. È iscritto all'Associazione Medici Cattolici e all'Associazione per la Lotta contro l’Infarto.
Nel 1997 è stato eletto consigliere comunale di Roma. Nel 2000 è stato eletto consigliere regionale del Lazio ed è stato Presidente della Commissione Trasporti, Lavori Pubblici, Viabilità nonché membro delle Commissioni Sanità e Affari Sociali della Regione Lazio. Nel 2008 è stato eletto Senatore della Repubblica nella lista del Pdl.
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